Major Collision Investigation Unit detectives have charged a 44-year-old man following a fatal collision in Ferntree Gully.

The Lilydale man has been charged with numerous offences including culpable driving causing death, reckless conduct endangering life and dangerous driving while pursued by police.

He remained in hospital where a bedside remand hearing was to be held.

The charges relate to the death of a 39-year-old woman following a three-vehicle collision on Ferntree Gully Road shortly after 5.30pm on Saturday, August 27.

The Knoxfield woman was the passenger in the vehicle allegedly being driven by the charged man.

The occupants in the two other vehicles were not seriously injured.

As the death occurred following contact with Police, as is standard procedure, Professional Standards Command will have oversight of the investigation.