Police charged 20 alleged offenders and impounded five vehicles as part of Operation Buchan, in Epping.
Concern about a rise in anti-social behaviour, drug use, impaired driving and theft offences around Cooper St led to the operation.
Cooper St is a key arterial route that experiences significant vehicle and pedestrian traffic across day and night.
Epping Police, along with officers from Mill Park Divisional Response Unit, State Highway Patrol and Air Wing, undertook the operation on Thursday-Friday, November 21-22.
Over two nights, 20 alleged offenders were charged with offences including possess drugs, unlicensed driving, possess weapons and theft.
Five vehicles were impounded as a result of licence and drug-driving offences.
A series of drivers found in possession of cannabis led to police executing a search warrant at a nearby Cooper St address on Saturday, November 23.
Officers allegedly located a traffickable amount of cannabis and other prescription medication.
A 53-year-old Epping woman was charged with traffick cannabis.
She was bailed to appear before Heidelberg Magistrates’ Court on March 3.