Major Collision Investigation Unit detectives are on the scene of a fatal collision which happened earlier this afternoon in Reedy Creek.

The collision occurred on the Strath Creek Rd when a car with four occupants left the roadway and rolled just before 1.30pm.

Paramedics worked on a female passenger but unfortunately she died at the scene.

Three other occupants, two men and a woman were conveyed to Melbourne hospitals in stable conditions.

Anyone who witnessed the collision is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppersvic.com.au